Session: Session 4

Comprehensive discovery lipidomic workflow which utilizes a novel, multi-reflecting ToF with integrated informatics, providing highly confident lipid characterization and quantification

Lipidomics allows studying changes in the lipidome as a result of disease, treatment, lifestyle, etc. Analysis of these lipids in a discovery mode is normally performed by a combination of liquid chromatography (LC) and accurate mass spectrometry (MS). Despite developments in analytical technology the detection and identification of lipids remains a significant challenge. Here we show the key benefits of XevoTM MRT MS and the features it provides to help overcome some of the drawbacks outlined for lipid analysis. Combining this novel MS data with third-party informatic solutions, demonstrates a powerful lipidomic workflow. The benefits of this approach are demonstrated using plasma samples from colon and rectum cancer and healthy control plasma.