Session: Parallel session 6 - Instrumental development
FTMS Booster: a high-performance data acquisition and processing system to advance FTMS applications
Hardware architectures of contemporary built-in data acquisition and processing (DAQ/P) systems in the FTMS instruments often remain sub-optimal in performance, including phase distortions requiring post-acquisition phase correction, reduced resolution and duty cycle, and compromised S/N and sensitivity. A direct consequence of these limitations is restricted access to the absorption mode FT (aFT) mass spectra. Furthermore, the current generation of built-in DAQ/P systems, accompanied by rigid data acquisition control software, may inhibit experimental flexibility, for instance, by prohibiting the stable acquisition of ultra-short or ultra-long time-domain transients.
Previously, we demonstrated that the state-of-the-art field-programmable-gate-array (FPGA) technology enables a new-generation DAQ/P architecture with powerful in-line digital signal processing helping to overcome the said disadvantages. The new-generation high-performance DAQ/P systems, e.g., the FTMS Boosters, can directly yield the in-hardware phased transients, which can be readily converted into equally informative aFT mass spectra. The flexibility of the external and in-parallel interfaced high-performance DAQ/P systems to commercial and custom FTMS instruments provides additional benefits.
We will overview recent advances in high-performance external phased transient acquisition and processing technology and its use in selected applications. The recent examples include advancing Orbitrap-, ICR-, and custom FTMS-based charge detection mass spectrometry (CDMS), mass spectrometry imaging and bottom-up/top-down proteomics applications [1-3].
[1] A. Kozhinov, A. Johnson, K. Nagornov et al., Anal. Chem., 95, 7, 3712–3719 (2023)
[2] A. Grgic, K. Nagornov, A. Kozhinov, et al., Anal. Chem. 96, 2, 794–801(2024)
[3] E. Deslignière et al., Nature Methods, DOI 10.1038/s41592-024-02207-8 (2024)