Session: Parallel session 2 - Ion mobility spectrometry

Tandem Ion Mobility and Conformational Changes in the Gas Phase

We will present an advanced instrument developed in Lyon, featuring two ion drift tubes separated by an ion trap, followed by a time-of-flight mass spectrometer. The first drift tube is designed to select a specific conformation, while the second drift tube monitors conformational changes occurring in the ion trap. This setup allows for collision and laser activation within the trap, as well as precise temperature control of the trap.

Initially, we will showcase examples of isomerization induced by both collision and laser irradiation. Subsequently, we will demonstrate how this instrument enables the acquisition of kinetic and thermodynamic data related to the conformational changes of peptide